Herein, we present a case-control study designed to assess the association between the levels of sex hormones (total testosterone and estradiol) and P450 aromatase levels based on single-nucleotide polymorphisms (SNPs) in the CYP19A1 gene to investigate the relationship between CYP19A1 and CAD in the Chinese population. This evidence concerns the gene CYP19A1 and coronary artery disorder.