After multivariate adjustment, CAD remained significantly associated with estradiol (OR = 0.889, 95% CI:0.817–0.969, P = 0.007) and aromatase (OR = 0.947, 95% CI:0.936–0.957, P = 0.000) but not testosterone (OR = 6.894, 95% CI:0.876–4.967, P = 0.067). The gene discussed is CYP19A1; the disease is coronary artery disorder.