Our results showed BALB/c female mice after receiving decorin at 3 months old only showed extensive inflammation before 6 months old, but after 6 months old NBF developed with extensive chronic inflammatory tissue hyperplasia including ankylosing joint, psoriasis-like skin disease, inflammation of eyes including blepharoconjunctivitis and iridocyclitis, and inflammatory cardiomyopathy. This evidence concerns the gene DCN and blepharoconjunctivitis.