In our study, Kaplan-Meier analysis revealed that double low expressions of CALR and PDIA3 were positively associated with poor OS in NSCLC and double high expressions were positively associated with better OS in NSCLC, which indicated CALR and PDIA3 played positive roles in the prognosis of NSCLC. This evidence concerns the gene PDIA3 and non-small cell lung carcinoma.