These analyses suggest that combination of CALR and PDIA3 is more advantageous to enhance an immune response and contribute to better clinical outcome in patients with NSCLC, which is in line with Cox regression analysis that combined expression of CALR and PDIA3 was an efficient biomarker for the prognosis and more accurate in prediction of NSCLC prognosis compared with CALR and PDIA3 expression alone. This evidence concerns the gene PDIA3 and non-small cell lung carcinoma.