Several polymorphisms of the RAGE gene had been suggested, and their associations with type 2 diabetes mellitus (T2DM) and T2DM related microvascular complications, such as diabetic retinopathy (DR) or DN had been reported previously [7–9], including (rs1800624 [−374T>A], rs1800625 [−429T>C], rs184003 [1704G>T] and rs2070600 [Gly82Ser]). Here, AGER is linked to diabetes mellitus.