ESR1 and breast neoplasm: Kaplan-Meier estimates of relapse-free survival over time (rfs_t) showed that high EGR1 gene expression levels were significantly correlated with favorable prognosis in at least two different datasets where breast tumors were treated with tamoxifen: in Symmans et al., GSE17705 [HR=0.38 (0.21–0.69); p = 0.00083] [19] and Loi et al., GSE6532 (ER+ samples on GPL96 platform) [HR=0.62(0.4–0.95); p = 0.028] [20] (Figure 2A and 2B).