While CK8+/+ and CK8+/− mice treated with AOM and DSS each developed colonic tumors, the tumor incidence was significantly greater in CK8+/− mice than in WT mice after the second cycle of DSS treatment (Figure 2C), and the colon length was shortened in the CK8+/− group (Figure 2D). The gene discussed is KRT8; the disease is infectious otitis media.