A few recent follow-ups on large cohorts of prospective carriers from Asia identified the presence of HBeAg and high levels of HBV DNA and ALT as independent risk factors for the subsequent development of cirrhosis and HCC [29–30].Although there was no evidence indicated that these factors had an impact on interval time between cirrhosis and HCC in patients with HBV-related cirrhosis etiology, but the analysis of these factors will make the results more reliable. This evidence concerns the gene GPT and hepatocellular carcinoma.