Interestingly, we observed that all 7 patients who had a clinical response to treatment (defined as reduction of splenomegaly and symptomatic improvement) showed overt down-regulation of CIP2A mRNA levels, ranging from -40% to -99.6% the baseline levels, while all the 7 patients who did not benefit from treatment (non responders) showed no changes or even an increase of CIP2A mRNA levels (Figure 4E). The gene discussed is CIP2A; the disease is Splenomegaly.