Results from these experiments, that are detailed in the respective Figure legends, indicated that BMK120 was able to effectively inhibit the proliferation, and induce apoptosis, of JAK2V617F mutated mouse and human cell lines, potently inhibit the growth of erythropoietin-independent erythroid colonies from MPN patients, and reduce the dissemination of Ba/F3 JAK2V617F-Luc+ mutated cells in mice prolonging their survival. This evidence concerns the gene EPO and myeloproliferative neoplasm.