In the current study, we have found that 1) MerTK-specific shRNA knockdown resulted in considerable growth inhibition and inducing apoptosis in MerTK-overexpressing GC cell lines; 2) MerTK protein overexpression by IHC was found in 8.3% (16/192) of GC patients, who were associated with a poor survival duration; 3) MerTK mRNA overexpression was found in 7.4% (4/54) cases of GC PDCs, which was comparable with the MerTK protein overexpression; and 4) UNC1062 inhibited tumor growth of MerTK-overexpressing cell lines and PDCs. This evidence concerns the gene MERTK and gastric cancer.