TNFSF11 and rheumatoid arthritis: In addition, the deformation of joint synovium by proliferating pannus was eliminated by PLAG treatment, and expression of receptor activator of NF-κB ligand (RANKL) in RA-FLSs was also inhibited by PLAG, suggesting that PLAG might also be effective in the regulation of osteoclast development (data not shown).