ANGPTL8 and hyperinsulinism: In response to acute hyperinsulinemia, circulating betatrophin levels in the controls were significantly and rapidly dropped down from 0.37 ± 0.16 to 0.15 ± 0.09 μg/L at 80 min, then to 0.17 ± 0.08 μg/L at 100 min, and to 0.18 ± 0.16 μg/L at 110 min, and finally to 0.15 ± 0.09 μg/L (all P <0.01 vs. 0 min).