In PCOS women with IR, after metformin administration, BMI, Fat%, TG, TC, HbA1c, fasting plasma insulin (FIns), 2-h plasma insulin after glucose overload (2-hIns), AUCglucose, AUCinsulin, HOMA-IR, testosterone (TEST), FAI were declined significantly, whereas sex hormone- binding globulin (SHBG) increased (P <0.05 or P<0.01; Supplementary Table 4). This evidence concerns the gene SHBG and polycystic ovary syndrome.