In PCOS women with IR, circulating betatrophin concentrations were similarly dropped from 0.51 ± 0.12 to 0.19 ± 0.10 μg/L at 80 min, then to 0.17 ± 0.08 μg/L at 100 min, and to 0.19 ± 0.06 μg/L at 110 min, and finally to 0.19 ± 0.08 μg/L at 120 min (all P<0.01 vs. 0 min, Figure 1E). This evidence concerns the gene ANGPTL8 and polycystic ovary syndrome.