TCF4 and schizophrenia: Next, we determined the overlap between TCF4 bound genes and de novo variants found in individuals with schizophrenia collated by Fromer et al.36 For schizophrenia de novos, statistically significant enrichment was observed for all classes of mutations bar silent mutations (table 2); all mutations (SCZ_all P = 5.25 × 10−7), loss of function mutations (SCZ_LoF P = 2.79 × 10−2) and nonsynonymous mutations (SCZ_NS, P = 1.26 × 10−5).