TCF4 and brain disorder: Notably, module 17 that contain genes involved in synaptic transmission are enriched for both inherited, common variant ASD-risk genes and TCF4 targets.46 Furthermore, a robust overlap exists between targets of the FMRP RNA-binding protein and genes implicated in a range of brain disorders including schizophrenia and ASD.36,55 We found that many TCF4 bound genes are also FMRP targets, including TCF4 itself (table 1).