FMR1 and schizophrenia: The targets of the FMRP-RNA binding protein and LoF intolerant genes are enriched for genes that harbor both de novo and common and risk alleles for schizophrenia and other neurodevelopmental disorders such as ASD and ID.4,36,47,48 TCF4 bound genes were also highly enriched for FMRP targets and LoF intolerant genes (OR = 1.87 and 1.42, respectively, P < 2.2 × 10−16) (table 1).