HOOK2 and type 2 diabetes mellitus: When we examined the CpG sites which were differentially methylated between T2D and NT2D samples, we found three positions (Illumina probes cg 11738485, cg 04657146 and cg 06417478) located in the intragenic region of chromosome 19, all of which overlay the same gene, HOOK2 (Hook Microtubule Tethering Protein 2) (Δβ ≥ 0.195) (Fig 1B).