For example, in subcutaneous adipose tissue from a group of 31 healthy men following exposure to exercise training [6], changes in methylation were found related to variations in mRNA expression in some of the T2D associated genes––HHEX (Hematopoietically-Expressed Homeobox Protein), IGF2BP2 (Insulin-like Growth Factor 2 Binding Protein 2), JAZF1 (JAZF Zinc Finger 1) and TCF7L2 (Transcription Factor 7-like 2). This evidence concerns the gene TCF7L2 and type 2 diabetes mellitus.