SH2B3 and colorectal cancer: SNPs in LD (R2=0.91) with rs7137828 include rs3184504 (48% frequency, p=4×10−8), a missense variant in the SH2B3 gene, associated with blood pressure, maternal birth weight, TNF-α levels, colorectal cancer, Inflammatory Bowel Disease, LDL cholesterol levels and stroke [14].