CDKN2A and peripheral vascular disease: Variants in the 9p21 region, which includes CDKN2B-AS1 (ANRIL) and CDKN2A/B, were also associated (lead SNP rs1556516, 49.8% frequency, p=4.7×10−16); this locus is involved in cellular senescence and associated with myocardial infarction and peripheral vascular disease [14].