For four of the novel parents' attained age-associated variants it is the rare allele that is associated with increased lifespan; rs602633 near CLESR2 and PSRC1; rs28383322 near HLA-DRB1 and HRL-DQA1; rs7844965 in EPHX2; and rs61978928 in PROX2. This is unusual, as for the other genetic variants it is the common allele that confers the advantage (the rare variant tends to be associated with increased disease-risk, such as CAD). Here, EPHX2 is linked to coronary artery disorder.