However, also within M-CLL, response to BCR inhibition was negatively correlated with TTT, and BCR inhibitors were significantly associated with TTT in multivariate models considering age, pretreatment, trisomy 12, del11q22.3, del17p13, TP53 mutation, and IGHV status (Supplemental Tables 8–10). Here, TP53 is linked to B-cell chronic lymphocytic leukemia.