By contrast, overexpression of Parkinson’s disease-linked alpha-Synuclein (Figure 9E,G) or Amyotrophic Lateral Sclerosis (ALS)-linked human SOD1 (Figure 9F,G) in larval eye disc failed to elevate Acn S437 phosphorylation compared to wild type (Figure 9A). This evidence concerns the gene SNCA and amyotrophic lateral sclerosis.