By contrast, overexpression of Parkinson’s disease-linked alpha-Synuclein (Figure 9E,G) or Amyotrophic Lateral Sclerosis (ALS)-linked human SOD1 (Figure 9F,G) in larval eye disc failed to elevate Acn S437 phosphorylation compared to wild type (Figure 9A). Here, ACIN1 is linked to amyotrophic lateral sclerosis.