CDK5 and early-onset autosomal dominant Alzheimer disease: This is consistent with increased Cdk5 activity reported for multiple Alzheimer’s disease models (Otth et al., 2002; Shah and Lahiri, 2017) which in turn may contribute to the Cdk5-dependent phosphorylation of Tau as a possible contribution to the progression of Alzheimer’s disease (Cruz et al., 2003).