NFE2L2 and tauopathy: Interestingly, MT enhances autophagy and clearance of aggregated tau protein in a transgenic mouse model at 0.05μM [42] and, at low dose, induces genes regulated by NF-E2-related factor 2 (Nrf2) which control pathways available for clearance of proteotoxic proteins in another transgenic tauopathy mouse model [43].