To determine whether replacement of each peptide alone can reverse the characteristic melanocortin obesity, we continuously administered incremental doses (0.03–3.00 nmol/25 g body weight/day) of α-MSH or desacetyl-α-MSH into adult Pomctm1/tm1 mouse brains over 14 days. This evidence concerns the gene STAMBP and obesity due to melanocortin 4 receptor deficiency.