This is a comparatively large study for metabolic profiling and is made possible by high‐throughput automated NMR metabolomics.21 This method also allowed quantification of lipids and detailed lipoprotein analysis in addition to metabolites.21 Additionally, we were careful to adjust for NT‐proBNP in both cohorts, a robust predictor of incident HF. This evidence concerns the gene NPPB and hydrops fetalis.