Moreover, after chimeric mice were intravenously infected with HBV genotype C derived from chronic hepatitis B patients, the expression of IFN-λ1, IFN-λ2, and IFN-λ3 mRNAs in the liver tissue was found to be increased at 4 or 5 weeks after infection [35]. This evidence concerns the gene IFNL2 and chronic hepatitis B virus infection.