In the best multiple logistic regression model assessed using stepwise backward regression, IFN-λ3 was the only positive determinant (OR 1.023, 95% CI 1.013–1.033, P = 5.3E − 6), whereas chronic glomerulonephritis (OR 0.208, 95% CI 0.079–0.544, P = 0.001) and ALT (OR 0.951, 95% CI 0.913–0.990, P = 0.015) were negative determinants of favourable outcome with respect to HBV vaccination and occurrence of HBV/HCV infections. Here, IFNL3 is linked to infection.