In this study, we did not show association of IFNL3 rs8099917 with circulating IFN-λ3 in the entire group of HD patients, which is in agreement with the results obtained by Aoki et al. [41] from Japanese patients with chronic hepatitis C. Lower intrahepatic expression of IFNL3 mRNA in HCV-infected liver recipients and donors was demonstrated in subjects harbouring a variant allele of rs8099917 [47]. Here, IFNL3 is linked to Huntington disease.