As shown in Table 4, the top rankings were related to Notch, cancer‐associated pathway, TGF‐beta, PI3K/Akt, HTLV infection, Hippo, HIF‐1, alcoholism signaling pathways, and so on (P < 0.05); among them, Notch, TGF‐beta, PI3K/Akt, and Hippo signaling pathways were well known to be associated with the pathogenesis of PAH. This evidence concerns the gene AKT1 and pulmonary arterial hypertension.