TNF and colitis: This probiotic ameliorated the damage caused by inflammation in dextran sulphate sodium (DSS)-induced colitis in mice (Hairul Islam et al., 2011) and LPS-induced stress in broilers (Li et al., 2015) by down-regulating expression of pro-inflammatory cytokines such as TNF α, IL1 β and IL2 and up-regulating the anti-inflammatory cytokine IL10 upon exacerbated inflammation.