Trifluridine/tipiracil is a new and valuable addition for the treatment of colorectal cancer, indicated for patients with metastatic colorectal cancer who have been previously treated with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, an anti-VEGF biologic therapy, and if RAS wild-type, an anti-EGFR therapy. This evidence concerns the gene VEGFA and metastatic colorectal cancer.