GH1 and cancer: Nevertheless, it appears to be a slight excess risk of second neoplasia related to GH therapy among “high-risk” children, including patients with syndromes, diseases, and mutations known to be associated with an inherent elevated risk for cancer and early mortality, such as those with neurofibromatosis type 1, Fanconi anemia, and Down syndrome, but no comparable data are available for patients with AGHD20.