Very recently while we were preparing this manuscript for publication, Niu et al. [18] published a paper showing that methylation tests of SDC2 in fecal DNA detects CRC and advanced adenoma (≥ 1.0 cm) with sensitivities of 81.1 and 58.2%, respectively, at a specificity of 93.3%. This evidence concerns the gene SDC2 and colorectal carcinoma.