To know how early such aberrant SDC2 methylation might occur during tumorigenesis of CRC, SDC2 methylation status was analyzed using bisulfite-pyrosequencing assay in tissue lesions with various severity, including hyperplastic polyps (n = 17), precancerous adenomatous (n = 32), and colorectal tumors (n = 18). This evidence concerns the gene SDC2 and hyperplastic polyp.