As the importance further declines, features which serve as common biomarkers in type 2 diabetes mellitus (T2D) appear (4-methyl-2-oxovaleric acid, 3-methyl-2-oxovaleric acid, fasting glucose, Matsuda index, and positive AUC for insulin) that all have higher concentrations in the “reduced phenotypic flexibility” group. The gene discussed is INS; the disease is diabetes mellitus.