INS and type 2 diabetes mellitus: There were no significant differences in the BMI values, body weight, fasting plasma glucose, or HbA1c in T2DM patients subdivided into carriers of the AA, GA and GG genotypes of the COMT Val108/158Met (Table 3), or when patients were subdivided into carriers of the CC, CT and TT of the DBH-1021C/T (Table 3), neither at baseline nor after 52 week treatment with insulin detemir.