CD274 and neoplasm: The two CheckMate studies were closely followed by two other positive phase III trials, again versus docetaxel, with pembrolizumab [80], a humanised antiPD1 IgG4 monoclonal antibody, which has been developed as single agent exclusively in PD-L1-expressing tumours, and atezolizumab [81], a humanised IgG1antibody against PD-L1.