CD274 and non-small cell lung carcinoma: The study showed a clear superiority of pembrolizumab in terms of PFS (median 10.3 vs 6.0 months; HR 0.50, p < 0.001), which was the primary endpoint, and OS (HR 0.60; p = 0.005), leading most guidelines to recommend PD-L1 testing in the diagnostic workout of patients with advanced NSCLC.