According to data from MLLrecombinome, the most frequent rearrangements occur either with MLLT3/AF9, MLLT1/ENL, ELL, MLLT10/AF10, MLLT4/AF6 or AFF1/AF4 genes, or are derived from gene internal duplications (MLL-PTDs) representing ~90% of AML cases. Here, AFF1 is linked to acute myeloid leukemia.