CYP2E1 and acute myeloid leukemia: Some studies have shown that certain haplotypes of CYP1A1 are associated with an increased risk for paediatric leukaemia (ALL and AML) whose parents are smokers (OR: 2.1) [73], while CYP2E1* 5 allele in heterozygosity was associated with the risk of AML in children in Turkey (OR: 4.9) [74].