The most frequent chromosomal abnormalities in children with AML (c-AML) older than two years are those associated with the core-binding factor (CBF) aberrations, such as t(8;21)(q22;q22)/RUNX1-RUNX1T1 and inv(16)(p13.1;q22)/CBFβ-MYH11. Here, RUNX1 is linked to acute myeloid leukemia.