In recent analysis of i-AML series in Brazil, the RUNX1-RUNX1T1, CBFβ-MYH1 and KMT2A (or MLL) rearrangements (KMT2A-r) and PML-RARA occurred in frequencies of 12.2%, 17.4%, 67.6% and 3.2%, respectively [6]. The gene discussed is KMT2A; the disease is acute myeloid leukemia.