The therapeutic potential of AF-MSCs and their secreted molecules in mice with acute hepatic failure has been analysed, and numerous proinflammatory mediators, regulating cytokines and growth factors in AF-MSC-conditioned media such as IL-10, IL-27, IL-17E, IL-12p70, IL-1β, and IL-1ra, were observed. The gene discussed is IL25; the disease is Acute hepatic failure.