In a setting where immunosuppression mediated by regulatory T cell (Treg) could represent one relevant mechanism for tumor immune evasion, work by Facciabene and colleagues nicely showed that tumor hypoxia promotes the recruitment of Tregs through inducing chemokine CC-chemokine ligand 28 (CCL28) expression, which, in turn, promotes angiogenesis and tumor tolerance (15). This evidence concerns the gene CCL28 and neoplasm.