Translation of these studies in a large animal model for hemophilia A showed that AAV-mediated liver gene transfer of canine FVIII was not only effective in long-term sustained expression of FVIII but may also eradicate pre-existing inhibitory antibodies in two strains of hemophilia A dogs, with indications for improving outcomes in patients with established inhibitors (93–95). The gene discussed is F8; the disease is hemophilia A.