SIRT1 and endothelial dysfunction: The decrease in SIRT1 deacetylase activity in the saline and SIRT1-inhibitor-treated muscles after moderate compression might have resulted from the complicated process of ischemia-reperfusion injury including reactive oxygen species, calcium overload, endothelial dysfunction, inflammatory response (Yellon and Hausenloy, 2007), and regulation via microRNAs (Revollo and Li, 2013).