AKT1 and hematopoietic and lymphoid system neoplasm: In particular, curcumin affects several signaling pathways known to be important for solid and blood cancers, such as the PI3k/Akt-1/mTOR pathway (Sokolosky et al., 2011; McCubrey et al., 2012; Zhao et al., 2016; Zhu et al., 2017), the Ras/Raf/MEK/ERK pathway (McCubrey et al., 2012), the GSK-3beta pathway (Yun et al., 2015), p53 activity (Sidhar and Giri, 2017), and NF-κB pathways (Marin et al., 2007).