Within the SHIP and SHIP-TREND cohorts, 2,018 individuals that were ≥60 years of age were diagnosed as diabetes-free (see description of the control population) and were subsequently analyzed for the p.Arg23Cys (rs8192618, genotyping data for 2,009 individuals available) and p.Ser49Leu (rs140960896, genotyping data for 2,018 individuals available) allele frequencies. This evidence concerns the gene INPP5D and diabetes mellitus.