SYN3 and Anxiety: As an initial validation of these findings, we tested for significance in an overlap with anxiety-related differentially methylated loci that we previously reported in the central nucleus of the amygdala of young monkeys26 and found a significant overlap (P-value < 0.05) of anxiety-related differentially methylated genes, including GNAS, SYN3, and JAG2 (Table 1).