Our previous studies suggested a role for circadian responsiveness to systemic l‐DOPA administration in the regulation of seasonal metabolism.7, 8, 9, 10 Other studies centred on clock region neurophysiology identified a potential cause‐effect relationship between a diminution of the circadian peak in dopamine release at the general peri‐SCN region and seasonal glucose intolerance.5, 6 However, the identification of specific dopaminergic neurones projecting to a peri‐SCN/SCN neural circuit that in turn regulates peripheral metabolism has not been established. Here, CLOCK is linked to Glucose intolerance.