MAPT and Alzheimer disease: Similarly, in rodent models, experimentally induced sleep disruption has been shown to lead to several interlinked processes, otherwise independently implicated in development and progression of AD: an accumulation of Aβ and tau pathology, an increase in CNS oxidative stress, and reduction of the structural and functional integrity of the blood brain barrier (Cedernaes et al., 2016, Heneka et al., 2015).