(Ju et al., 2016) Another hallmark of AD, tau pathology, has been shown to start early in the disease process in neurons in the medial temporal lobe, more specifically in the trans-entorhinal region, and to spread to the hippocampus and amygdala, and later to the neocortical association areas (Blennow et al., 2006). Here, MAPT is linked to Alzheimer disease.