In addition to these two common hotspots identified on chromosome 5: 1,295,228 C > T (C228T) and 1,295,250 C > T (C250T), the tandem mutations of 1,295,228/1,295,229 CC > TT (C228T/C229T) and 1,295,242/1,295,243 CC > TT (C242T/C243T) have also been reported in melanoma with TERT promoter mutation. The gene discussed is TERT; the disease is melanoma.