TP53 and B-cell chronic lymphocytic leukemia: The CLL-IPI scores these risk factors as follows: 17p deletion [del(17p])/TP53 (deleted/mutated) = 4; immunoglobulin heavy-chain variable-region (IGVH) not mutated = 2; β2-microglobulin > 3.5 mg/L = 2; clinical stage (Rai I–VI or Binet B–C) = 1; and age > 65 years = 1.