A recent study of isolated mesenchymal elements sorted directly from low-risk MDS BM patients by the markers CD45−/7AAD−/CD235a−/CD31−/CD271+/CD105+ describes a different transcriptomic signature of MSCs from MDS patients in comparison with normal MSCs or cultured MDS-MSCs. The gene discussed is PECAM1; the disease is myelodysplastic syndrome.