Injection of an IL-15 super-agonist, in which IL-15 was bound to soluble IL-15Rα (IL-15/IL-15Rα) into NSG mice engrafted with human-peripheral blood mononuclear cells (PBMCs) activated the human NK population and inhibited acute HIV-1 infection after viral challenge18. The gene discussed is IL15; the disease is HIV-1 infection.