Also, insulin like growth factor binding protein 2 (Igfbp2), was among the top down-regulated genes (Supplementary Table S6), a result consistent with previous studies indicating that Igfbp2 modulates insulin sensitivity and that low levels of Igfbp2 are associated with type 2 Diabetes (T2DM)16. Here, IGFBP2 is linked to type 2 diabetes mellitus.