ZDHHC3 and nervous system disorder: Finally, treatment of HFD mice with the non-specific palmitoylation inhibitor, 2-BP, completely rescued hippocampal synaptic plasticity and memory deficits (Fig. 6a–e), thus suggesting the potential efficacy of 2-BP and/or other more specific drugs targeting zDHHC3 in metabolic-dependent cognitive impairment, as well as in other neurological diseases associated with altered plasticity involving AMPARs.