This counter-intuitive finding could be due to the protective effect of the use of medications such as statins, angiotensin-converting-enzyme inhibitors, and calcium channel blockers, which improve arterial stiffness.23, 24, 25 Sensitivity analyses of ischaemic heart disease participants, stratified by medication use versus no medication use, confirmed that only those who did not use medication had attenuated reductions in pulse wave velocity and augmentation index after the Oxford Street walk compared with those after Hyde Park walks. The gene discussed is ACE; the disease is heart disorder.