Furthermore, gantenerumab treatment was associated with a dose-dependent reduction in CSF biomarkers that are thought to reflect core pathological processes of AD, including hyperphosphorylation of tau (p-tau), and downstream processes of neuronal and axonal degeneration (t-tau) [23], as well as synaptic dysfunction (neurogranin) [24]. This evidence concerns the gene NRGN and Alzheimer disease.