Eight differentially expressed isoforms encoded by OGDH, COL6A3, ICAM1, PHPT1, PPP2R5D, SLC29A1, and TRIB3, further validated by qRT-PCR, resulted up-regulated in CRC, providing evidence about tumor specific alternative transcripts of genes involved in metabolism, which putatively play a role in CRC. This evidence concerns the gene PPP2R5D and colorectal carcinoma.