In CRC patients, one variant was classified likely pathogenic (MSH2, c.186_187 dup), two with uncertain relevance (EXO1, c.2212-1G > C; POLD2, c.203G > T) and 36 with unknown significance (in EXO1, LIG1, MLH1, MLH3, MSH3, MSH6, PMS1, PMS2, POLD1, RPA1 genes). The gene discussed is MSH6; the disease is colorectal carcinoma.