Li et al. [100] used 20 CRC cell lines to identify 20 top genes responsible for resistance/sensitivity to irinotecan and further validated 7 of them (CDC20, CTNNAL1, FZD7, CITED2, ABR, ARHGEF7 and RNMT) by qPCR in two resistant and sensitive CRC cell lines. The gene discussed is ARHGEF7; the disease is colorectal carcinoma.