Further supporting the contribution of overactivation of TGFBR1 in granulosa cells to ovarian tumorigenesis in the TGFBR1-CAG9Cre model, mice harboring TGFBR1CA and Zp3-Cre, which is expressed in growing oocytes, but not non-growing oocytes of primordial follicles [19], did not develop ovarian tumors, regardless of the parental origin of Cre transmission (Y. Gao and Q. Li, unpublished observation). The gene discussed is TGFBR1; the disease is ovarian neoplasm.