NQO1 gene P187S polymorphism (C609T mutation) can destroy the stability of the enzymecausing loss of activity, so the function of benzene poisoning protection is destructive, the polymorphism can increase the risk of hematotoxicity and leukemia in breast cancer, non-smoking lung cancer and people exposed to benzene [31–34]. The gene discussed is NQO1; the disease is breast cancer.