DNMT1 and metastatic malignant neoplasm in the lymph nodes: However, DNMT1 overexpression in patients with lymph node metastasis (N2, N1-3) and distant metastasis (M0, M1) showed a long overall survival time (P < 0.05, Figure 5C–5F), and those in stage III and stage IV also showed a good outcome for OS (P < 0.05, Figure 5G, 5H).